Eli Lilly's Evista cancer drug approved by FDA

It's interesting when a drug is re-purposed into something aimed at fighting cancer, but that is what has happened to Evista, a prescription drug made by Eli Lilly which was originally for osteoporosis patients.

The FDA has officially approved Evista for use in breast cancer patients as of late this week, although the drug will now come with a box warning advising patients of a heightened risk for stroke by taking the drug.

I'm not sure -- are some drugs worth the possible benefits when certain side effects can be just as bad as what is trying to be treated?

Eli Lilly's Evista cancer drug approved by FDA

10 Tips for Reducing Cancer Risk

While we can’t always prevent cancer, we can do things to help reduce the risk of developing it. Of course, we always hear: eat healthy foods, exercise, don’t smoke. But the message doesn’t seem to be getting through because people still eat junk or high fat foods, still don’t exercise and still smoke.

The Mayo Clinic published 10 tips to reduce cancer risk in their most recent issue of Mayo Clinic Women’s HealthSource.

Here are the tips and below there’s more explanation:

1. Stop smoking
2. Limit alcohol intake – some alcohol is okay, too much is not
3. Follow recommended intake of fruits and vegetable (daily!)
4. Decrease the amount of fat in your daily diet
5. Lose weight if you’re too heavy, try to gain weight if you’re too thin
6. Move! Get active
7. Watch your skin (from the sun and don’t use tanning beds)
8. Don’t take chances when having sex. Protect yourself.
9. See your doctor regularly and take part in recommenced screening tests
10. If you have had cancer or are at particularly high risk, speak with your doctor about chemoprevention, which is taking medications to reduce the risk of new cancers

How and why do these steps help?
First of all, none of these are a surprise. All these recommendations, save for the last one, are recommended to help reduce the risk of developing many health problems, such as type 2 diabetes, hypertension, heart disease, and more. So by following these tips, you’re helping your body more than you may realize.

Smoking: Did you know that smoking not only increases your risk of developing lung cancer, but also mouth (tongue, cheek, palate, throat, gum) cancer? Your risk of bladder cancer also climbs quite a bit. Smoking affects your whole body, not just your lungs. Also, the social act of smoking is often accompanied by other not-so-healthy lifestyle factors, like drinking alcohol, limiting exercise, and so on. By quitting the cigarettes, your risk drops every day you’re no longer a smoker.

Alcohol: Many of us like to enjoy a good glass of wine, a cold bottle of beer, a good scotch – and many of us limit ourselves to a moderate number of glasses. However, if you drink too much, more than the recommended amount for your sex, you increase your risk of mouth, pharynx, larynx, esophagus, liver, colon and rectum cancers.

Fruits and vegetables: It’s not that difficult to add the recommended amounts of fruits and vegetables into your daily diet, but it does take planning. Unfortunately, with the hectic lifestyles many people lead these days, food planning often goes out the door. Five servings of fruits and vegetables daily are the minimal amount that you should be taking in. The thing is, servings are not huge, so this is not impossible. Two and a half cups of fruits or vegetables over the course of the day is maybe one apple, one tomato and a couple of stalks of celery. That’s not too much, is it?

Limiting fat: This one may be of the easiest things to do. Fat is an essential part of the human diet; we need it for our body to function properly. However, the type of fat and the amount you get is important.
This table, from the USDA, shows you how much fat you should have according to the number of calories you should have per day:

Total Calorie Intake	Limit on Saturated Fat Intake
1,600	18 g or less
2,000a	20 g or less
2,200	24 g or less
2,500a	25 g or less
2,800	31 g or less

And this table, from the same source, gives you an idea of what foods have what fat:

Food Category	Portion	Saturated Fat Content (grams)	Calories
Cheese Regular cheddar cheese Low-fat cheddar cheese	1 oz 1 oz	6.0 1.2	114 49
Ground beef Regular ground beef (25% fat) Extra lean ground beef (5% fat)	3 oz (cooked) 3 oz (cooked)	6.1 2.6	236 148
Milk Whole milk (3.25%) Low-fat (1%) milk	1 cup 1 cup	4.6 1.5	146 102
Breads Croissant (med) Bagel, oat bran (4″)	1 medium 1 medium	6.6 0.2	231 227
Frozen desserts Regular ice cream Frozen yogurt, low-fat	1/2 cup 1/2 cup	4.9 2.0	145 110
Table spreads Butter Soft margarine with zero trans fats	1 tsp 1 tsp	2.4 0.7	34 25
Chicken Fried chicken (leg with skin) Roasted chicken (breast no skin)	3 oz (cooked) 3 oz (cooked)	3.3 0.9	212 140
Fish Fried fish Baked fish	3 oz 3 oz	2.8 1.5	195 129

Source: ARS Nutrient Database for Standard Reference, Release 17.

Weight control: Being a healthy weight for your body build helps your body in many ways. It can even help reduce the pain of osteoarthritis for some people. Being too thin also has health issues, so keep that in mind if you are trying to lose weight.

Get active: Enough said!

Watch your skin: Tanning is not beautiful – any change in your skin color means there is damage going on. Don’t use tanning beds – they’re even worse than the sun. Plus, too much sun exposure doesn’t just contribute to skin cancer, it makes your skin old, dry and wrinkly well before its time.

Protect yourself from sexually transmitted infections: Sex with people without protection exposes you to hepatitis and HIV, both of which are very high risk for cancer, let alone the disease itself. Human papillomavirus (HPV) causes genital warts, some of which can cause cervical cancer, cancer of the cervix.

Screening tests: Screening tests for prostate cancer, cervical cancer, breast cancer, are all over the news, but don’t forget the other screenings that you can have done. You can have a colonoscopy to check for the beginnings of colon cancer and you can have your skin checked regularly to look for signs of skin cancer. If you are at high risk of a particular type of cancer, speak with your doctor about screening for that, as well. And, don’t forget your dentist. He or she is the one who can detect signs of oral cancer.

Chemoprevention: This is a relatively new area, most commonly known for women who take Tamoxifen to help reduce the risk of breast cancer coming back. You may want to speak with your doctor about this if you are at a high risk of cancer or you have already had it.

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Blistree.com

10 Tips for Reducing Cancer Risk

Understanding Cancer - Symptoms

What Are the Symptoms of Cancer?

In its early stages, cancer usually has no symptoms, but eventually a malignant tumor will grow large enough to be detected. As it continues to grow, it may press on nerves and produce pain, penetrate blood vessels and cause bleeding, or interfere with the function of a body organ or system.

The Seven Warning Signs of Cancer

To remember the seven early warning signs of cancer (as designated by the American Cancer Society), think of the word CAUTION:
C hange in bowel or bladder habits.
A sore that does not heal.
U nusual bleeding or discharge.
T hickening or lump in the breast, testicles, or elsewhere.
I ndigestion or difficulty swallowing.
O bvious change in the size, color, shape, or thickness of a wart, mole, or mouth sore.
N agging cough or hoarseness.
The following symptoms may also signal the presence of some form of cancer:

• Persistent headaches
• Unexplained loss of weight or appetite
• Chronic pain in bones
• Persistent fatigue, nausea, or vomiting
• Persistent low-grade fever, either constant or intermittent
• Repeated instances of infection

Call Your Doctor About Cancer If:

You develop symptoms that may signal cancer, are not clearly linked to another cause, and persist for more than two weeks. You should schedule a medical examination. If the cause of your symptoms is cancer, early diagnosis and treatment will offer a better chance of cure.

Understanding Cancer - Symptoms

What really Cancer is?

Cancer (medical term: malignant neoplasm) is a class of diseases in which a group of cells display uncontrolled growth (division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via lymph or blood). These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, and do not invade or metastasize. Most cancers form a tumor but some, like leukemia, do not. The branch of medicine concerned with the study, diagnosis, treatment, and prevention of cancer is oncology.

Cancer may affect people at all ages, even fetuses, but the risk for most varieties increases with age. Cancer causes about 13% of all human deaths. According to the American Cancer Society, 7.6 million people died from cancer in the world during 2007. Cancers can affect all animals.

Nearly all cancers are caused by abnormalities in the genetic material of the transformed cells. These abnormalities may be due to the effects of carcinogens, such as tobacco smoke, radiation, chemicals, or infectious agents. Other cancer-promoting genetic abnormalities may be randomly acquired through errors in DNA replication, or are inherited, and thus present in all cells from birth. The heritability of cancers is usually affected by complex interactions between carcinogens and the host's genome. New aspects of the genetics of cancer pathogenesis, such as DNA methylation, and microRNAs are increasingly recognized as important.

Genetic abnormalities found in cancer typically affect two general classes of genes. Cancer-promoting oncogenes are typically activated in cancer cells, giving those cells new properties, such as hyperactive growth and division, protection against programmed cell death, loss of respect for normal tissue boundaries, and the ability to become established in diverse tissue environments. Tumor suppressor genes are then inactivated in cancer cells, resulting in the loss of normal functions in those cells, such as accurate DNA replication, control over the cell cycle, orientation and adhesion within tissues, and interaction with protective cells of the immune system.

Diagnosis usually requires the histologic examination of a tissue biopsy specimen by a pathologist, although the initial indication of malignancy can be symptoms or radiographic imaging abnormalities. Most cancers can be treated and some cured, depending on the specific type, location, and stage. Once diagnosed, cancer is usually treated with a combination of surgery, chemotherapy and radiotherapy. As research develops, treatments are becoming more specific for different varieties of cancer. There has been significant progress in the development of targeted therapy drugs that act specifically on detectable molecular abnormalities in certain tumors, and which minimize damage to normal cells. The prognosis of cancer patients is most influenced by the type of cancer, as well as the stage, or extent of the disease. In addition, histologic grading and the presence of specific molecular markers can also be useful in establishing prognosis, as well as in determining individual treatments.

What really Cancer is?

Welcome to Cancer Survival Guide

There are more than 100 types of cancer. Lung, Breast, Skin, and Colon cancers, in addition to covering topics relevant to all cancers. Learn the preventative measures you can take to protect yourself, and find out more about the latest mainstream and alternative cancer treatments, as well as how to manage the disease if you've been diagnosed.

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Welcome to Cancer Survival Guide